Santa Croce Vacations from $781

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Your Santa Croce Vacation

Discover the best that Santa Croce offers with a Santa Croce vacation package. From its culture to every other thing that makes it special, this neighborhood will charm you from beginning to end. When it's time to take in the sights, you'll find loads of popular attractions nearby including Rialto Bridge, St. Marks Basilica and St. Marks Square. Visit one, two or more during your trip to Santa Croce. Don't just dream it — do it! Lock in your ideal Santa Croce vacation with Expedia and experience travel your way.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Ca' Alvise

Hotel Ca' Alvise

4 out of 5
Venice City Center
Save 100% on your flight
per person
Nov 7 - Nov 12
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Venice (VCE)
8.4/10 Very Good! (607 reviews)
Friendly staff, great location!

Reviewed on Aug 12, 2025

Baglioni Hotel Luna - The Leading Hotels of the World

Baglioni Hotel Luna - The Leading Hotels of the World

5 out of 5
Venice City Center
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9.4/10 Exceptional! (1,000 reviews)
I loved staying here. The hotel is sooooo conveniently located....can't imagine anything better. Right next to a water taxi, and from my windows, I could see Dior, Tiffany and Hermes! A girl's dream location! :) If I'm ever back in Venice, and I hope that'll be the case, I would most definitely stay here again and will recommend to my friends.

Reviewed on Aug 11, 2025

Hotel San Moisè

Hotel San Moisè

3 out of 5
Venice City Center
Save 100% on your flight
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
7.8/10 Good! (710 reviews)
Quaint Venetian room

Reviewed on Aug 7, 2025

Hotel Marconi

Hotel Marconi

3 out of 5
Venice City Center
Save 100% on your flight
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
7.8/10 Good! (1,009 reviews)
Hotel was near to most of the attractions and we could even walk (about 20 minutes) to train station to catch a train to Padova. The hotel staff was very friendly, especially the front desk person (I think he is philipino). He helped us with clarifying places to go, catching a water bus/taxi, etc. The breakfast included in our stay and it was wonderful. They had sausages, eggs, bacon, ham, bread, many sweets, drinks, tea/coffee, etc. It was one of the best I have seen for breakfast included hotel stays. Also, hotel is on the Grand Canal and they have few chairs and two tables in front of the hotel for their guests to enjoy in evenings or day time near the canal. There were lot of dining options nearby. Hotel was very responsive to my messages through Expedia and even arranged a taxi from airport to hotel at late night. We stayed with 2 kids and we were very happy with our stay and would deycome back.

Reviewed on Aug 5, 2025

Cà Bonfadini Historic Experience

Cà Bonfadini Historic Experience

5 out of 5
Cannaregio
Save 100% on your flight
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9.8/10 Exceptional! (194 reviews)
We absolutely loved our stay here. Definitely a 5* experience. Lovely staff, great decor, unique room (we were in superior double). Good location. Fantastic breakfast - I had a omelette and it was the best out of all places we have stayed on holiday.

Reviewed on Aug 3, 2025

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Dorsoduro featuring heritage architecture and a coastal town

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center

Santa Croce Hotel Deals

Hotel Arlecchino

Hotel Arlecchino

3 out of 5
Fondamenta Delle Burchielle, Santa Croce 390, Venice, VE
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $119 total per night from Aug 24 to Aug 25
$119 total
Aug 24 - Aug 25
Total includes taxes and fees
9/10 Wonderful! (995 reviews)
"Perfect location"

Reviewed on Aug 9, 2025

Hotel Arlecchino
Hotel Carlton on the Grand Canal

Hotel Carlton on the Grand Canal

4 out of 5
Sestiere Di Santa Croce 578, Venice, VE
Fully refundableReserve now, pay when you stay
$165 nightly
The price is $192 total per night from Aug 18 to Aug 19
$192 total
Aug 18 - Aug 19
Total includes taxes and fees
8.2/10 Very Good! (1,005 reviews)
"Amazing hotel right on the grand canal and opposite the train station. The view was astounding, and the staff were all super friendly. The food was superb, and the rooftop bar was awesome for watching the sun set over Venice."

Reviewed on Aug 11, 2025

Hotel Carlton on the Grand Canal
Hotel Al Duca Di Venezia

Hotel Al Duca Di Venezia

3 out of 5
Fontego dei Turchi 1739 Santa Croce, Venice, VE
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $181 total per night from Aug 24 to Aug 25
$181 total
Aug 24 - Aug 25
Total includes taxes and fees
9/10 Wonderful! (992 reviews)
Loved my stay
"We had a large 2 room suite, beds and pillows were very comfy. Service was great and so was the morning breakfast."

Reviewed on Aug 5, 2025

Hotel Al Duca Di Venezia
See all 5,822 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Ca'Pesaro

Ca'Pesaro

You can browse the exhibits at Ca'Pesaro, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the churches in the area.

Ca'Pesaro
Fondaco dei Turchi

Fondaco dei Turchi

5/5(4 reviews)

You can browse the exhibits at Fondaco dei Turchi, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the churches in the area.

Fondaco dei Turchi
#LifeatExpedia #Waterlust #GoldenHour #TroveOn #Architecture

Tolentini

Learn about the local history of Venice when you take a trip to Tolentini. Visit the area's churches or amble around its marina.

Tolentini

Things to do

Venice: Leonardo Da Vinci Museum Entrance Ticket

Venice: Leonardo Da Vinci Museum Entrance Ticket

$9
per adult
76% of travellers recommend
Venice: Leonardo Da Vinci Museum Entrance Ticket
Venice: St. Mark’s Basilica Skip-the-Line Tour & Gondola Ride Experience

Venice: St. Mark’s Basilica Skip-the-Line Tour & Gondola Ride Experience

$73
per adult
90% of travellers recommend
Venice: St. Mark’s Basilica Skip-the-Line Tour & Gondola Ride Experience
From Milan: Varenna, Bellagio & Como Day Trip

From Milan: Varenna, Bellagio, and Como Day Trip

$128
per adult
From Milan: Varenna, Bellagio, and Como Day Trip
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.